Study Explains L-Threonate’s Effect on Magnesium in the Brain

Magtein has shown brain-health benefits in past animal and human studies, but new research offers further insight into the mechanism by which L-threonate supports transmission of magnesium in the brain.

Writing in Neuropharmacology, researchers report that L-threonate “directly induced” an increase of intracellular magnesium concentrations in cultured rat hippocampal neurons. L-threonate was found to boost mitochondrial membrane potential and increase functional synapse density in neuronal cultures, allowing for a greater amount of magnesium to be absorbed in the cerebrospinal fluids and neurons. “These effects are unique to threonate, as other common [magnesium] anions failed to have the same results,” concluded researchers. They added that L-threonate’s observed effects were mediated through glucose transporters. In addition to the rat neural cells, researchers also evaluated the effect of L-threonate in human neural stem–cell derived neurons. They found that it was just as effective at upregulating synapse density in the human in vitro model as in the rat in vitro model. “This new body of research is ground-breaking in that it explains at the molecular level why Magtein is so effective in cognitive function,” said Jennifer Gu, PhD, chief science officer at […]